Immunohistochemistry for histone h3g34w and h3k36m is. It is necessary to differentiate chondroblastoma from other. The cytologic diagnosis of chondroblastoma was confirmed on both. It typically arises in the epiphysis of a long bone. Although generally benign, chondroblastoma is placed in the. The surgical excision histomorphologic findings confirmed the initial diagnosis of lowgrade ccc made on cytology sample preoperatively. In 1931, codman classified it as a chondromatous variant of giant cell tumors, when he described these lesions in the proximal humerus.
The pap test and bethesda 2014 american cancer society. There is radiographic evidence of allograft incorporation and no evidence of local recurrence. Nov 01, 2000 read cytological features of chondroblastoma. Webpathology is a free educational resource with 10236 high quality pathology images of benign and malignant neoplasms and related entities. For language access assistance, contact the ncats public information officer. Histologic examination of the lesion disclosed a benign chondroblastoma. If you have problems viewing pdf files, download the latest version of adobe reader. This publication is a thorough guide to diagnostic cytology. Chondroblastoma is a benign bone tumor arising most often in the epiphyses of long bones. Chondroblastoma pediatric orthopaedic society of north. Fine needle aspiration cytology of chondroblastoma of bone.
They occur mostly in the second decade of life and is more common in males. Case report with cytopathologic and histopathologic study francesco longo, md,luigi califano, md,f aldo zupi, md, ddsj and franco fulciniti, md chondroblastoma is a rare benign neoplasm of bone. Fine needle aspiration cytology of chondroblastoma of the. Chondroblastoma accounts for cytology fnac has evolved as a simple, safe, and noninvasive preoperative tool in the diagnosis of bone tumors. The approach is often utilized to detect cancer, however, can also be assists in the identification of specific infectious diseases and other inflammatory conditions. A chondroblastoma is a rare type of noncancerous bone tumor that begins in cartilage. Home orthopedic bone tumors i benign chondroblastoma chondroblastoma. Chondroblastoma is a rare benign neoplasm of cartilaginous origin. Chondroblastoma definition of chondroblastoma by medical.
The patient is on followup with disease free interval of more than 5 years. Chondroblastoma is an uncommon benign bone tumour, which is locally aggressive 14, and arises from a secondary ossification centre in epiphyseal plates and apophyses 57. Pdf chondroblastoma of the lumbar spine a case report. Ewing first described this calcifying giant cell tumor, subsequently designated as epiphyseal chondromatous giant cell tumor by codman in 1931. There are helpful tables in the book that summaries the content and make learning easier. This bestselling book provides you with a comprehensive guide to the diagnostic applications of exfoliative and aspiration cytology. Chondroblastoma is a rare, cartilage producing primary neoplasm of the bone. Older age of presentation for skull lesions is reported. Helpful features which suggest a clear cell chondrosarcoma include. Chondroblastoma of the temporal bone thieme connect. To get it, download color textbook of histology pdf for free. Since the past few decades fine needle aspiration cytology fnac has gained momentum in preoperative diagnosis of bone lesions.
Department of pathology, leiden university medical center, leiden, the netherlands. Continue reading to learn more about chondroblastoma or visit the bone and soft tissue tumor program page to learn about our expertise and treatment options for this condition. Chondroblastoma is a rare, benign, locally aggressive bone tumor that typically affects the epiphyses or apophyses of long bones. Pdf comprehensive cytopathology e book download read.
The official designation of a primary bone tumor as a chondroblastoma depends on the histologic finding of foci of chondroid matrix, andor ch. The bethesda system for reporting cervical cytology. Pdf fine needle aspiration cytology of chondroblastoma. Chondroblastoma of the craniofacial skeleton is extremely rare, with most cases occurring in the squamosal portion of the temporal bone. Chondroblastoma danafarberboston childrens cancer and. Chondroblastoma vs clear cell chondrosarcoma radiology. Dec 03, 2018 a chondroblastoma is a rare, usually benign, tumor of bone that accounts for approximately 1% of all bone tumors. Aug 14, 2019 chondroblastoma is an uncommon benign cartilage producing neoplasm with a characteristic epiphyseal location. Ct guided radiofrequency ablation minimally invasive approach may be indicated for selected small tumors. The term chondroblastoma was coined by jaffe and lichtenstein in 1942. Case report and differential diagnosis with other soft tissue tumors, diagnostic cytopathology on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at. Publication date 1921 topics natural sciences, biological sciences in general, general genetics. Chondroblastoma of the knee treated with resection and.
In this report, we describe the first case of chondroblastoma of the clivus presenting with cranial neuropathy that was treated with endoscopic endonasal resection. Fine needle aspiration cytology of chondroblastoma. It is thought to arise from an outgrowth of immature cartilage cells chondroblasts from secondary ossification centers, originating from the. At oneyear followup the patient was pain free and has obtained excellent range of motion. Role of diagnostic cytology, collection and preparation of material for cytodiagnosis, cytopreparatory. There were eight female and four male patients age range, 11. Lower recurrence rate in chondroblastoma using extended. Pdf fine needle aspiration cytology of chondroblastoma of. Free cytology books download ebooks online textbooks. This report documents the cytological features of two cases of chondroblastomas diagnosed by cytology.
Between 1979 and 1987 12 patients with chondroblastoma underwent fine needle aspiration fna. Distinguishing between a chondroblastoma and an epiphyseal clear cell chondrosarcoma can be difficult. Therapy for chondroblastoma consists primarily of surgical curettage. With numerous illustrations to enthuse the reader and make cytological practice a more. Age of occurrence is usually between 10 and 25 years with a male predominance. Varies with time early hypercellularity, followed by necrosis, followed by fibrous or chondroid areas with occasional spindle cells. We report a case of chondroblastoma arising in the lumbar spine in a 25yearold man who presented with low back pain of 5 years duration.
A chondroblastoma is a rare, usually benign, tumor of bone that accounts for approximately 1% of all bone tumors. In patients who are skeletally immature still growing there is always a risk of growth plate failure from the chondroblastoma since it usually grows adjacent to the growth plate and may damage it. Chondroblastoma is a rare benign bone tumor of chondroblast origin that almost always occurs in a primary or secondary site of ossification, suggesting possible derivation from cartilage growth plates. Chondroblastoma of the knee treated with resection and osteochondral allograft reconstruction. The differential is that of other lesions which have a predilection for the epiphysis or apophysis see differential for an epiphyseal lesion. Manual for cytology pdf 44p this book covers the following topics. We present a case of primary benign chondroblastoma cutis in a 19yearold man. Chondroblastoma is a rare type of benign noncancerous tumor that grows at the ends of the bodys long bones, close to the joints. Ncert books pdf download 2020 for class 12, 11, 10, 9, 8. A pelvic metastatic mammary carcinoma was misinterpreted by fnac as a chondrosarcoma. Pdf chondroblastoma is a rare, giant cellrich, benign neoplasm of bone.
Chondroblastoma accounts for approximately 12 % of all primary bone tumours. Extraskeletal origin of chondroblastoma is a rarity and virulent behavior by its local aggressive nature or metastasis is reported in very few cases. Most often, the tumors develop at the ends of the femur thighbone, tibia shinbone, or humerus upper arm bone. Chondroblastoma is uncommon, representing jess than i % of all bone tumors and approximately 3% of all benign bone tumors in the mayo clinic files. Chondroblastoma is a cartilageforming, benign bone tumor. Chondroblastoma of the temporal bone is a rare condition.
Commonly seen in the epiphyses and apophyses of long bones in adolescents and young adults. Martin and ellis 1 first applied this technique to the diagnosis of bone lesions in 1930. Get a printable copy pdf file of the complete article 3. Pdf chondroblastoma is a rare benign cartilaginous tumor typically seen in long bones, especially femur, tibia and proximal humerus. Ncert books pdf free download for class 12, 11, 10, 9, 8, 7, 6, 5, 4, 3, 2, and 1 april 14, 2020 by kishen 16 comments there are many books in the market but. Clear cell chondrosarcoma diagnosed by fine needle aspiration. Role of diagnostic cytology, collection and preparation of material for cytodiagnosis, cytopreparatory techniques of serous effusions, fixation of cytology specimens, staining methods in cytology. They typically occur in children and young adults, and are more common in males. Chondroblastoma is a rare benign primary bone tumor.
Chondroblastoma is an uncommon osseous neoplasm that accounts for less than 1% of all bone tumours. Genetic and rare diseases information center gard po box 8126, gaithersburg, md 208988126 toll free. Chondroblastoma, a destructive lesion with a thin radiodense border, is usually seen in the epiphysis of long bones. Chondroblastoma is a rare benign cartilaginous tumor typically seen in long bones, especially femur, tibia and proximal humerus. Diagnostic cytology pdf cytology is the study of cellsdiagnostic cytology involves analyzing cells to identify ailments. Chondroblastoma is a rare, giant cellrich, benign neoplasm of bone. Chondroblastoma accounts for less than 1% of all bone tumors. Links to pubmed are also available for selected references. It is thought to arise from an outgrowth of immature cartilage cells chondroblasts from secondary ossification centers, originating from the epiphyseal plate or some remnant of it. From january 1987 through december 1992, 22 patients with histologically confirmed chondroblastoma and prior mr imaging examinations were seen. There are many different types of cartilage in the body. Nov 18, 20 chondroblastoma is a rare benign bone tumor of chondroblast origin that almost always occurs in a primary or secondary site of ossification, suggesting possible derivation from cartilage growth plates. Since the past few decades fine needle aspiration cytology fnac has gained.
Case report and differential diagnosis with other soft tissue tumors, diagnostic cytopathology on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. The book takes a systemic approach and covers the recognized normal and abnormal cytological findings encountered in a particular organ. Pdf chondroblastoma of the lumbar spine a case report and. Chondroblastoma and chondromyxoid fibroma abstract chondroblastoma and chondromyxoid. All site content, except where otherwise noted, is licensed under a creative commons attributionnoncommercialshare alike 3. Download diagnostic cytology pdf free download and read. Chondroblastoma is an uncommon benign cartilage producing neoplasm with a characteristic epiphyseal location. In 1942, henry l jaffe 18961979 and louis lichtenstein 19061977, american physicians and pathologists, designated this tumor as a benign chondroblastoma of bone 12. The mass encroached on the left neural foramen on magnetic resonance imaging. Local recurrence after such therapy occurs in approximately 15% of cases, 171, 173, 174 with time to recurrence ranging from 5 months to 8 years.
Compact polyhedral chondroblasts with abundant pink cytoplasm and variable pigment, well defined cell borders and hyperlobulated nuclei with grooves in mineralized, chicken wire matrix that surrounds chondroblasts. It characteristically arises in the epiphysis or epimetaphyseal region of long bones and has been reported to affect people of all ages with slight male predilection. Benign chondroblastomas of bone comprise approximately 1 per cent of benign primary bone. The tumor, which developed in the skin on the left temple behind the auricle, was surgically removed. Given the location and possible involvement of the articular surface of the knee and the physical demands of this demographic this benign bone tumor and its conventional surgical treatment can be a significant source of morbidity. Cytology cytology the study of the structure and function of cells cells are. Intraoperative crush smear cytology of vertebral chondroblastoma. An introduction is a succinct book which guides the trainee through the hurdles of early cytology practice and can also be used throughout the career as an aide memoire by the more experienced. Chrondroblastoma is a benign tumor of bone with slow and selflimited growth, 1% of all bone tumors. Download color textbook of histology pdf 3rd edition. This section contains free ebooks and guides on cytology, some of the resources in this section can be viewed online and some of them can be downloaded. Pdf chondroblastoma is an uncommon osseous neoplasm that accounts for less than 1% of all bone tumours. Oct 01, 20 this website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment.
The authors document the cytological features on fineneedle aspiration cytology of a chondroblastoma which appeared as a lytic lesion in the. At cytology, other giant cellrich tumors and tumorlike lesions such as aneurysmal bone cyst abc, giant cell tumor, and chondromyxoid fibroma. Chondroblastoma is a rare primary bone tumor of young people fine needle aspiration cytology of chondroblastoma of bone. Between 1991 and 2001, liquidbased cytology, automation, computerassisted imaging, and hpv testing were introduced and increasingly utilized in laboratories that offered cervical cytology testing. Who has defined chondroblastoma as a benign, cartilageproducing neoplasm usually arising in the epiphyses of. Chondroblastoma genetic and rare diseases information. Jun 30, 2019 chondroblastoma is an uncommon benign cartilage producing neoplasm with a characteristic epiphyseal location. Plain radiography and computed tomography revealed a welldefined osteolytic mass surrounded by marginal sclerosis in the third lumbar verte bra.
This is the tough, rubbery connective tissue from which most bones develop. Chondroblastoma is a rare benign primary bone tumor commonly presenting in the knee of young patients 3, 5. Full text is available as a scanned copy of the original print version. To define the characteristics of chondroblastoma at magnetic resonance mr imaging and the combination of findings that are diagnostic for chondroblastoma. The author has updated the book over time so that it can reflect the latest advancements in the field. Chondroblastoma is a rare neoplasm accounting for less than 1% of all bone tumors. Who has defined chondroblastoma as a benign, cartilageproducing neoplasm usually arising in the epiphyses of skeletally.
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